ABSTRACT
Relevance: studies of the effectiveness of large-scale medico-social experiments (MSE) are quite rare. On the one hand, MSE is, as a rule, a response to force ma-jeure circumstances, which should not be at all in ordinary live. On the other hand, such experiments, as well as their study, are processes characterized by high cost and considerable duration. Nevertheless, the example of COVID-19 regional prevention shows that coordinated interaction of various parts of the social organism can and should be carried out in a critical situation, that the effectiveness of this interaction should be quantified using integrative indicators of sanitary statistics. This interaction illustrates the spontaneous formation of a regional model of preventive healthcare of the future, which is characterized by active socio-economic and information-cognitive support of the main preventive and (or) treatment and diagnostic process aimed at the population of the region using a wide range of activities, including traditional and new educational technologies. Gol: to evaluate the medical effectiveness of the first pre-vaccination year of COVID-19 prevention at the regional level using integrative quantitative indicators of sanitary statistics. Methods: historical, statistical, graphical, linear regression analysis, system analysis and synthesis, organizational and methodological modeling. Results: the slope coefficients in the linear regression formulas corresponding to the annual growth rate (GR) on the graphs of prevalence and incidence in the studied social groups indicated that in the pre-pandemic years, the prevalence in the population was permanently growing-GR was within from +17 to +49 ‰ per year, and the incidence showed relative stability-GR was in the range from +8 to +12 ‰, and even decreased in the children’s population (-17 ‰ annually). Comprehensive preventive measures of the first pandemic year (2020) reversed the general growth trend and accelerated the process significantly. Thus, incidence GR was in the range from-35 to-257 ‰, and prevalence GR-from-179 to-326 ‰. Conclusion: preventive measures against COVID-19, carried out in the form of a large-scale MSE, made it possible to introduce at the regional level a model of systemic integrated preventive healthcare of the future, the medical effectiveness of which is many times greater than the previous organizational and methodological model of “autonomous” healthcare, as far as this can be judged by the emerging trends of change integrative indicators of health (prevalence and incidence). © 2022, Science and Innovation Center Publishing House. All rights reserved.